Table 3.
HRs for progression to ESRD by categories of eGFR and ACRa
| Parameter | eGFR (ml/min per 1.73 m2)
|
|||
|---|---|---|---|---|
| ≥60 | 45 to 59 | 30 to 44 | 15 to 29 | |
| Normal ACR | ||||
| unadjusted | 1.0b | 30.8 (9.3 to 102.2)b | 76.0 (18.5 to 313.2)b | 583.1 (120.5 to 2822.0)c |
| adjusted | 1.0b | 23.4 (6.7 to 82.1)b | 51.9 (11.5 to 233.5)b | 368.7 (69.2 to 1964.0)c |
| Microalbuminuria | ||||
| unadjusted | 33.9 (11.2 to 102.6)b | 227.4 (72.8 to 710.2)c | 740.6 (246.7 to 2222.0)c | 3833.0 (1265.0 to 11,611.0)d |
| adjusted | 27.3 (8.8 to 84.5)b | 146.5 (42.7 to 502.7)c | 448.9 (133.7 to 1508.0)c | 2202.0 (632.5 to 7669.0)d |
| Macroalbuminuria | ||||
| unadjusted | 306.6 (50.3 to 1871.0)c | 1108.0 (285.8 to 4297.0)c | 3167.0 (1066.0 to 9403.0)d | 6957.0 (2286.0 to 21,165.0)d |
| adjusted | 196.3 (27.6 to 1397.0)c | 641.1 (143.6 to 2862.0)c | 2036.0 (594.3 to 6973.0)d | 4146.0 (1187.0 to 14,482.0)d |
a
Numbers are unadjusted HR (95% CI) and HR after adjustment for age, gender, systolic BP, antihypertensive medication, diabetes, HDL cholesterol, and physical activity in a Cox regression analysis. Microalbuminuria was ACR ranging from 20 to 200 mg/g in men and 30 to 300 mg/g in women.
b
Low risk for progression to ESRD.
c
Medium risk for progression to ESRD.
d
High risk for progression to ESRD.