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Effects of salt-deficient diet on plasma renin activity. Salt-free diet for 1 wk (0 NaCl) increased plasma renin activity seven-fold in the wild-type but only 3.4-fold in GPR91−/− mice. Data were normalized to wild-type normal salt intake (control [C] group) to show fold increases in plasma renin activity. *P < 0.05 DM GPR91+/+ versus DM GPR91−/−; #P < 0.05 C versus DM GPR91+/+ (n = 3 each).
