Figure 1.

Four groups based on urine protein:creatinine ratio and serum creatinine: Mean urine protein:creatinine ratio data for four groups of rats. Progressor rats had an initial biphasic peak of proteinuria followed by high level proteinuria until reaching ESKD. Limited proteinuric rats had a single peak of proteinuria that returned to close to control levels. Control and nonproteinuric groups are superimposable and had no increased proteinuria. Serum creatinine values measured at 6 mo or at ESKD were as follows: Control 0.37 ± 0.09 mg/dl; nonproteinuric 0.37 ± 0.10 mg/dl; limited proteinuric 0.30 ± 0.12 mg/dl; progressors 3.03 ± 0.46 mg/dl. Progressors had significantly higher values compared with other groups (P < 0.01, by Kruskal-Wallis test and Scheffe test).