Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Apr 9;6:36. doi: 10.1186/1742-4690-6-36

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2009 Schmökel et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Modulation of receptor expressed by human PBMC by SIVsmm nef alleles. (A) PBMCs (panels A-D) were transduced with HIV-1 NL4-3 constructs coexpressing the indicated nef alleles and GFP and assayed for surface expression of CD4, CD3, CD28 and MHC-I. The ranges of eGFP expression used to calculate receptor modulation are indicated. (B) Quantitative assessment of SIVsmm Nef-mediated down-modulation of the indicated cellular receptors. The animal specifications and SIVsmm lineages are indicated and the activities obtained using the SIVmac Nef are shown for comparison. Values give averages ± SD derived from three independent experiments. The asterisks denote a statistical significance (P < 0.05) between SIVmac239 and SIVsmm Nef activity. All SIV nef alleles were significantly (P < 0.001) more active than that of HIV-1 in modulating CD3, whereas the HIV-1 nef was more active (P < 0.05) than all SIVsmm nefs in down-regulation of MHC-I.