Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2009 Apr 9;6:36. doi: 10.1186/1742-4690-6-36

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2009 Schmökel et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Modulation of T activation by SIVsmm nef alleles. (A) PBMCs were transduced with replication-competent VSV G pseudotyped HIV-1 particles expressing either GFP alone (panel 1) or together with the HIV-1 NL4-3 and NA7 (panels 2 and 3), 239 wt (panel 4) or SIVsmm nef alleles (panels 5 to 12) and stained for CD69 and CD25 expression. Similar results were obtained in two independent experiments. (B) CD69 and CD25 expression levels on PBMCs infected with HIV-1 constructs coexpressing eGFP and the indicated nef alleles are shown relative to those measured on T cells transduced with the nef defective control virus (100%). Values give averages ± SD derived from three independent experiments. The asterisks denote a statistical significance (P < 0.05) between HIV-1 and SIV Nef activity.