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View full-text article in PMC

. 2009 Apr 9;6:36. doi: 10.1186/1742-4690-6-36

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Copyright © 2009 Schmökel et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Enhancement of viral replication by SIVsmm nef alleles. (A) Replication kinetics of recombinant NL4-3 variants containing the indicated nef alleles in PBMCs are shown. Infections were performed using virus stocks containing 1 ng p24 antigen. The numbers of virally infected GFP⁺cells was measured by flow cytometric analysis. Similar results were obtained in two independent experiments (B) Cumulative numbers of HIV-1-infected GFP⁺cells detected in PBMC cultures at days 3, 5 and 7 post-infection. Shown are averages ± SD derived from three independent infections. All nef alleles significantly (P < 0.05) enhanced the number of HIV-1-infected cells compared to the nef-defective control virus.