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. 2009 Apr 8;9:26. doi: 10.1186/1471-213X-9-26

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Copyright © 2009 Miclea et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Skeletogenesis is severely impaired in Col2a1-Cre;Apc^15lox/15loxembryos. (A-E) Greatly impaired skeletal development and growth arrest of Col2a1-Cre;Apc^15lox/15loxembryos. Gross appearance (A-C) and Alcian blue and Alizarin red staining (D-E) of skeletal preparations of Col2a1-Cre;Apc^15lox/15loxembryos and control littermates at indicated developmental stages. Conditional Apc mutants showed lack of mandible outgrowth (arrowheads), poor limb development (black arrows), and an open thoracic and abdominal cavity (red arrows). Scale bars: 1 mm.