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. 2009 Apr 8;9:26. doi: 10.1186/1471-213X-9-26

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Copyright © 2009 Miclea et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abnormal axial skeleton formation of Col2a1-Cre;Apc^15lox/15loxembryos already detectable at E12.5. (A) Immunostaining for β-catenin combined with Alcian blue (AB) staining, and (B-E) gene expression analysis by in situ hybridization with indicated probes on consecutive transversal sections of the sclerotome of a Col2a1-Cre;Apc^15lox/15loxembryo and control littermate at E12.5. (F-J) Similar analysis of vertebrae primordia at E14.5. β-Catenin-positive spindle-shaped cells lacked expression of all indicated chondrogenic and osteogenic markers (arrowheads). Scale bars: 100 μm.