Figure 3.

Absence of locomotor sensitization in DKO mice after chronic cocaine treatment. A–D, Mice were tested on day 1 with a 10 mg/kg acute dose of cocaine. On days 2–6, they received 20 mg/kg intraperitoneal cocaine injections in their home cage. On day 8, they received a 10 mg/kg challenge dose of cocaine. Ambulatory distance traveled on days 1 and 8 is shown for WT(AC1^+/+), AC1^−/−, AC8^−/−, and DKO mice. E, Summary data. WT, AC1^−/−, and AC8^−/− mice sensitize significantly to chronic cocaine, whereas DKO mice do not. n = 10–13 mice per group analyzed by two-way ANOVA, **p < 0.01 (Tukey's post hoc test).