Table 1.

Free parameters of the model used in the simulations in Figs 1–4

Parameter		Target	Lower boundary	Upper boundary
Ra	Ω cm	100	90	250
Rm	Ω cm2	21 000	10 000	60 000
Cm	μF cm−2	1.5	0.5	1.5
GIh	pS μm−2	12	0	50
Epassive	mV	−65	−70	0
GNa,dend	pS μm−2	10	0	100
GNa,soma	pS μm−2	50	0	100
GKf,soma	pS μm−2	65	0	100
GKf,dend	pS μm−2	70	0	100
GKs,soma	pS μm−2	15	0	100
GKs,dend	pS μm−2	90	0	100
Nadist	μm	1 000	0	1000
Ks, dist	μm	900	0	1000
Kf, dist	μm	500	0	1000
GNa,node	pS μm−2	31000	—	—
Nashift,act	mV	−7	—	—
Nashift,inact	mV	−8	—	—
GKf,node	pS μm−2	7 800	—	—
GKs,node	pS μm−2	1 500	—	—

The values of the target data set and the ranges over which the genetic algorithm searched for each parameter are given. The values describing axonal properties do not have parameter search ranges since they were used only to generate a training data set but were not included in the parameter data set constrained by the genetic algorithm. The passive parameters are the membrane resistance (R_m), axial resistance (R_a), the membrane capacitance (C_m) and the passive reversal potential of E_passive. The parameters describing the voltage-gated Na⁺ conductance are the somatic conductance density (G_Na,soma), the nodal conductance density (G_Na,node), the dendritic conductance density (G_Na,dend), the distance along the dendrite over which the conductance density changes from its somatic value to the dendritic value (Na_dist), the shift in the voltage of half activation (Na_shift,act) and the shift in the voltage of half inactivation (Na_shift,inact). The parameters describing the K_f conductance are the somatic conductance density (G_Kf,soma), the nodal conductance density (G_Kf,node), the dendritic conductance density (G_Kf,dend) and the distance along the dendrite over which the conductance density changes from its somatic value to the dendritic value (K_f,dist). The parameters describing the K_s conductance are the somatic conductance density (G_Ks,soma), the nodal conductance density (G_Ks,node), the dendritic conductance density (G_Ks,dend) and the distance along the dendrite over which the conductance density changes from its somatic value to the dendritic value (K_s,dist). The I_h conductance was described just by the conductance density (G_Ih).