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. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Immunol Rev. 2009 Mar;228(1):170–183. doi: 10.1111/j.1600-065X.2008.00751.x

Fig. 1. Abl kinases are activated in response to TCR engagement and regulate downstream signaling events.

Fig. 1

Abl kinases are activated in response to TCR stimulation in a pathway that requires Lck kinase activity. The activated Abl kinases promote the phosphorylation of ZAP-70 and LAT leading to activation of IL-2 transcription. Abl kinases also regulate actin polymerization through the Abi/Wave complex and HS1. The Wave complex promotes actin polymerization downstream of activated Rac leading to Arp2/3-mediated actin polymerization. The role of Abi and Wave phosphorylation by Abl is unclear. HS1 is also phosphorylated by Abl and regulates F-actin stabilization.