Skip to main content
. Author manuscript; available in PMC: 2010 Mar 1.
Published in final edited form as: Immunol Rev. 2009 Mar;228(1):170–183. doi: 10.1111/j.1600-065X.2008.00751.x

Fig. 4. Abl kinases regulate TCR-mediated integrin activation and adhesion.

Fig. 4

Abl kinases interact with the Wave protein complex and regulate Rap1 activation via CrkL-C3G resulting in inside-out integrin activation and adhesion. Wave also regulates TCR-mediated integrin clustering and high affinity binding through the recruitment of a complex containing Arp2/3, vinculin, and talin.