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(A) S100A8 and (B) S100A9 aggregation propensity profiles denoted at pH 7.0 by red, at pH 2.0 – by turquoise and in the natively folded S100A8/A9 complex – by blue lines, respectively. Calcium-binding sites are indicated by green, α-helices – by black and β-strands – by blue bars, respectively.
