Table 2.
Hazard ratios for cancer specific and all cause mortality for patients with specified co-morbidities
| Crude HR | Adjusted for pt factors1 | Adjusted for pt and disease factors2 | ||||
|---|---|---|---|---|---|---|
| Cancer specific mortality | ||||||
| Angina | 0.74 | 0.48–1.15 | 0.75 | 0.48–1.19 | 0.81 | 0.51–1.30 |
| Hypertension | 0.97 | 0.74–1.27 | 0.96 | 0.72–1.28 | 0.92 | 0.69–1.23 |
| Previous MI | 1.23 | 0.77–1.97 | 1.30 | 0.81–2.11 | 1.49 | 0.90–2.46 |
| Cardiac arrhythmias | 0.82 | 0.54–1.25 | 0.88 | 0.57–1.36 | 1.17 | 0.74–1.83 |
| CHF | 1.13 | 0.74–1.75 | 1.10 | 0.70–1.72 | 1.83 | 1.14–2.93 |
| PVD | 0.64 | 0.26–1.55 | 0.71 | 0.39–1.75 | 1.18 | 0.48–2.93 |
| Chronic respiratory disease | 1.16 | 0.85–1.58 | 1.06 | 0.77–1.46 | 1.24 | 0.89–1.74 |
| GI ulcer disease | 0.49 | 0.20–1.18 | 0.50 | 0.21–1.22 | 0.76 | 0.31–1.87 |
| Other cancer | 0.77 | 0.36–1.63 | 0.79 | 0.37–1.71 | 0.71 | 0.32–1.55 |
| Cerebrovasc disease | 1.23 | 0.75–2.02 | 1.30 | 0.78–2.16 | 1.25 | 0.74–2.10 |
| Diabetes (all) | 1.18 | 0.84–1.68 | 1.14 | 0.79–1.63 | 1.27 | 0.88–1.84 |
| Renal disease (all) | 1.10 | 0.60–2.01 | 1.01 | 0.54–1.87 | 1.42 | 0.76–2.66 |
| Other neurological | 1.19 | 0.71–1.97 | 1.35 | 0.80–2.25 | 1.96 | 1.12–3.42 |
| Charlson comorbidity index | ||||||
| O | 1.00 | 1.00 | 1.00 | |||
| 1–2 | 1.26 | 0.96–1.66 | 1.22 | 0.91–1.64 | 1.32 | 0.98–1.77 |
| 3+ | 0.86 | 0.52–1.42 | 0.88 | 0.53–1.47 | 1.48 | 0.88–2.50 |
| Number of conditions* | ||||||
| 0 | 1.00 | 1.00 | 1.00 | |||
| 1 | 1.30 | 0.93–1.80 | 1.29 | 0.92–1.83 | 1.06 | 0.76–1.55 |
| 2 | 1.15 | 0.79–1.68 | 1.13 | 0.75–1.70 | 1.23 | 0.81–1.87 |
| 3+ | 1.00 | 0.69–1.45 | 1.01 | 0.67–1.53 | 1.33 | 0.87–2.04 |
| All-cause mortality | ||||||
| Angina | 0.96 | 0.68–1.34 | 0.86 | 0.61–1.23 | 0.91 | 0.63–1.31 |
| Hypertension | 1.03 | 0.82–1.29 | 0.93 | 0.73–1.19 | 0.90 | 0.70–1.15 |
| Previous MI | 1.67 | 1.17–2.38 | 1.74 | 1.21–2.52 | 1.91 | 1.31–2.79 |
| Cardiac arrhythmias | 1.26 | 0.93–1.72 | 1.19 | 0.86–1.65 | 1.48 | 1.07–2.06 |
| CHF | 1.79 | 1.31–2.45 | 1.61 | 1.16–2.24 | 2.30 | 1.63–3.25 |
| PVD | 1.46 | 0.87–2.46 | 1.40 | 0.82–2.40 | 2.02 | 1.18–3.48 |
| Chronic respiratory disease | 1.29 | 0.99–1.66 | 1.12 | 0.85–1.46 | 1.26 | 0.96–1.66 |
| GI ulcer disease | 0.61 | 0.32–1.19 | 0.60 | 0.31–1.17 | 0.76 | 0.38–1.49 |
| Other cancer | 1.31 | 0.79–2.16 | 1.25 | 0.74–2.10 | 1.16 | 0.68–1.98 |
| Cerebrovasc disease | 1.36 | 0.91–2.04 | 1.28 | 0.85–1.93 | 1.27 | 0.84–1.94 |
| Diabetes (all) | 1.48 | 1.12–1.95 | 1.44 | 1.08–1.92 | 1.53 | 1.15–2.05 |
| Renal disease (all) | 1.52 | 0.96–2.39 | 1.32 | 0.83–2.10 | 1.79 | 1.12–2.86 |
| Other neurological | 1.44 | 0.97–2.16 | 1.58 | 1.05–2.38 | 2.02 | 1.32–3.11 |
| CCI | ||||||
| O | 1.00 | 1.00 | 1.00 | |||
| 1–2 | 1.68 | 1.32–2.14 | 1.55 | 1.20–2.00 | 1.60 | 1.24–2.07 |
| 3+ | 1.84 | 1.30–2.60 | 1.78 | 1.24–2.55 | 2.63 | 1.82–3.81 |
| Number of conditions* | ||||||
| 0 | 1.00 | 1.00 | 1.00 | |||
| 1 | 1.30 | 0.95–1.78 | 1.26 | 0.92–1.73 | 1.08 | 0.78–1.49 |
| 2 | 1.50 | 1.08–2.08 | 1.40 | 0.98–1.99 | 1.45 | 1.01–2.07 |
| 3+ | 1.73 | 1.28–2.35 | 1.63 | 1.17–2.28 | 2.00 | 1.41–2.82 |
1 includes age, sex, ethnicity, NZdep, year of registration, smoking
2 includes age, sex, ethnicity, NZdep, year of registration, smoking, stage, grade and site of cancer
* Included all conditions included in Charlson Comorbidity Index as well as angina, hypertension, cardiac arrhythmias, previous pulmonary embolism, cardiac valve disease, inflammatory bowel disease, other neurological conditions (including multiple sclerosis, Parkinson's disease, epilepsy) and major psychiatric conditions (including schizophrenia, bipolar disease and depressive psychosis)