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. Author manuscript; available in PMC: 2009 Nov 1.
Published in final edited form as: Nat Genet. 2009 Apr 6;41(5):625–629. doi: 10.1038/ng.346

Figure 4.

Figure 4

Evolutionary dynamics of hot-spot S2. Simulations were performed on populations each seeded 70,000 years ago with a single S9.1A->G mutation, then allowed to evolve by random mating with crossovers occurring in S9.1A/G heterozygotes at the mean frequency seen in sperm and assuming no female crossover activity (sex-averaged crossover rate of 0.083%). Transmissions into crossover progeny were biased against S9.1G at the mean level seen in sperm crossovers (A:G 0.743:0.257). Four examples of simulations that achieved the contemporary S9.1G frequency of 3.4% (circle) are shown (solid lines). Simulations into the future (dashed lines) used the same population and crossover parameters.