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Effect of TG content of islets on β-cell function. (A) Insulin secretory response to glucose in perfused pancreata of normal rats. (B) Insulin response to glucose in pancreata from fat-depleted hyperleptinemic rats perfused with or without FA in the perfusate. (C) Insulin response to glucose of fat-laden pancreata from obese, diabetic (fa/fa) ZDF rats. IRI, immunoreactive insulin.
