Fig. 2.

fMRI results for the novel vs. familiar contrast in the encoding task. (A) Mean activation for the novel vs. familiar contrast for all 36 subjects. Activation was found bilaterally in primary and secondary visual cortices as well as in regions involved in memory processes: hippocampus, temporal fusiform cortex, parahippocampal gyrus. (B) Regions of significantly increased BOLD for ε4-carriers relative to noncarriers. Activation in the right hippocampus and cerebellum was greater in the APOE ε4-carriers than in the noncarriers (P < 0.05, corrected for multiple comparisons). Red-to-yellow colors define increases in brain activation. R, right hemisphere; L, left hemisphere.