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A single i.p. injection of recombinant PAL enzyme (100 units at zero time), reduces plasma phenylalanine level in ENU1/1 mice by 95% at 24 hr (P < 0.02) relative to sham-treated controls. Data for five paired series (mean ± 1 SD) are normalized to paired control values to accommodate inter- and intraindividual variation. The range of control values (100% at zero time) was 41–528 μmol/liter; every animal showed a response to PAL.
