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Plasma phenylalanine levels in ENU2/2 mice after combined oral administration of naked PAL enzyme (200 units per mouse) and protease inhibitor (aprotinin): 50% reduction within 1 hr (P < 0.017) and 54% in 2 hr (P < 0.023). Data are normalized to control values (mean ± 1 SD). ■, Sham; ●, unprotected PAL plus aprotinin. The range of control values (100%) was 458–1,051 μmol/liter; every animal showed a response to PAL.
