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. Author manuscript; available in PMC: 2009 Sep 11.
Published in final edited form as: Cell Host Microbe. 2008 Sep 11;4(3):229–238. doi: 10.1016/j.chom.2008.08.004

Figure 1. Structure of the DENV E Protein and Its Arrangement on the Virion.

Figure 1

(A) Ribbon diagram of the antiparallel DENV E protein dimer as seen from the top and side. Individual domains of the E protein are indicated, as is the fusion loop at the distal end of E-DII. The N-linked carbohydrate modifications on E are shown as brown spheres

(B–D) Surface shaded representation of the DENV virion at varying stages of maturation as determined by cryo-EM reconstruction. The significant conformational differences in the organization of E proteins of the virion during maturation are evident by comparing structure of spiky immature virions at (B) neutral and (C) acidic pH. In the latter case, prM is represented in cyan and the icosahedral asymmetry unit is indicated as a gray triangle. In (D), the structure of the mature DENV virion is shown. The images presented in (B)–(D) were created using previously described structures of DENV (Kuhn et al., 2002; Yu et al., 2008; Zhang et al., 2003).