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. Author manuscript; available in PMC: 2009 May 7.
Published in final edited form as: Genes Immun. 2008 Jun 5;9(6):509–521. doi: 10.1038/gene.2008.43

Figure 8.

Figure 8

NOD activating Ly49 function. Splenic NK cells cultured in the presence of IL-2 from B6, 129S1, and NOD mice were prepared and used in chromium release assays against (a) CHO, and (b) YB2/0 target cells. Killing of CHO cells is largely dependent on competent signaling through the activating Ly49D receptor. Each line on the cytotoxicity graph indicates the killing achieved from ALAK cultures of different individual mice. (c) Three mice each of the indicated strains were injected i.p. with 5000 PFU MCMV and after three days spleen homogenates were prepared and used to infect BALB/c MEF monolayers to assess plaque forming potential. Data are shown in log scale with standard deviation. ND, not detectable.