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. Author manuscript; available in PMC: 2009 May 7.
Published in final edited form as: Methods Mol Biol. 2009;485:185–195. doi: 10.1007/978-1-59745-170-3_13

Fig. 13.1. The HIV-1 assembly pathway.

Fig. 13.1

Studies of assembly, initially in a cell-free system and subsequently in cells, has revealed that newly synthesized HIV-1 Gag progresses through a series of post-translational assembly intermediates of increasing size (10S, 80S, 150S, and 500S intermediates) before producing the completely assembled 750S immature capsid. This pathway requires ATP at a discrete step as indicated and also requires the cellular ATPase ABCE1, which associates with selected assembly intermediates.