Fig. 4.

Simulating the effect of PKC activation. Although the HCSP is enlarged much more than the RRP (A, compare with Fig. 2A), the insulin secretion profile during fast bursting is hardly modified because the first and second phases are enhanced to a similar degree (B, compare with Fig. 3A). The mobilization rate in A was enhanced 3-fold relative to Fig. 2A to represent the effect of PKC. In B, the rate before glucose stimulation was also increased 3-fold and then further increased to 5-fold over basal to represent the effect of glucose on mobilization (vs. the factor 3 used in Fig. 3A). The docking rate r₃ was decreased 50% to simulate stabilization of the HCSP granules.