Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
NMR investigation of rimantadine binding to the WT and S31N mutant. (A) Strips from 3D 15N-edited NOESY spectra (110 NOE mixing time) recorded for WT(18–60) and S31N(18–60) in the presence of rimantadine, indicating the absence of drug binding to the S31N mutant at the lipid-facing pocket. (B) WT(18–60) and S31N(18–60) methyl spectra show that the S31N mutation greatly reduced exchange broadening of the methyl-baring residues in the lipid-facing pocket.
