TABLE 6.
Fold-increases in antibody titers in rabbits immunized with F. tularensis LVS.
| Antibody | Antigen | Dose (CFU) | Scarification |
Subcutaneous |
||
|---|---|---|---|---|---|---|
| Day 16 | Day 50 | Day 16 | Day 50 | |||
| IgM | LVS | 1x106 | 422 (223–774) | 51 (27–139) | 343 (98–3,522) | 94 (36–422) |
| 1x108 | 4,902 (2,510–8,609) | 1,203 (662–1,992) | 2,198 (1,726–2,889) | 938 (499–1,881) | ||
| Schu-S4 | 1x106 | 229 (130–467) | 26 (14–65) | 350 (103–3,972) | 79 (36–448) | |
| 1x108 | 3,056 (1,520–5,959) | 604 (317–939) | 2,290 (1,906–2,654) | 789 (381–1,584) | ||
| IgA | LVS | 1x106 | 114 (72–176) | 74 (45–153) | 96 (24–846) | 27 (13–46) |
| 1x108 | 813 (566–1,428) | 253 (64–922) | 550 (391–906) | 139 (69–201) | ||
| Schu-S4 | 1x106 | 125 (71–191) | 49 (31–87) | 64 (20–596) | 21 (10–29) | |
| 1x108 | 780 (567–1,049) | 297 (119–657) | 309 (206–589) | 101 (46–157) | ||
| IgG | LVS | 1x106 | 394 (163–1,232) | 653 (316–2,381) | 501 (55–5,738) | 675 (49–4,795) |
| 1x108 | 3,555 (2,322–5,488) | 3,474 (1,016–11,021) | 896 (487–1,498) | 2,876 (1,219–11,315) | ||
| Schu-S4 | 1x106 | 215 (100–630) | 396 (243–745) | 167 (25–2,981) | 460 (60–1,151) | |
| 1x108 | 2,232 (1,464–3,306) | 2,391 (1,132–5,143) | 740 (474–1,265) | 1,861 (744–6,577) | ||
F. tularensis LVS was administered to rabbits as described in Table 2. Data represent Geometric Mean fold increases in antibody titers and ranges (in parenthesis) for vaccinated groups compared with placebo.