TABLE 7.
Microagglutination titers in rabbits immunized with F. tularensis LVS.
| Group | Dose (CFU) | Scarification |
Subcutaneous |
||
|---|---|---|---|---|---|
| Day 16 | Day 50 | Day 16 | Day 50 | ||
| LVS | 1x106 | 80* (40–160) | 13 (10–40) | 57 (20–320) | 25 (5–40) |
| 1x108 | 359* (320–640) | 113 (40–320) | 403* (160–640) | 180 (80–320) | |
| Placebo | 5 | 5 | 5 | 5 | |
LVS was administered to rabbits as described in Table 2. Data represent GMT and range of titers. Antibody responses in vaccinated groups were significantly higher than those observed in placebo groups (P<0.001) except for rabbits that received 1x106 by scarification; titers were higher in rabbits that received 1x108 CFU both on days 16 and 50 (P <0.01).
*
P <0.05 titers were higher on day 16 than on day 50 except for rabbits that received 1x106 by SC route.