. Author manuscript; available in PMC: 2009 May 7.

Published in final edited form as: Curr Drug Abuse Rev. 2008 Nov;1(3):303–327. doi: 10.2174/1874473710801030303

Table 3.

Pharmacological Actions of GABAergic Agents in Animal Models or Paradigms of Psychostimulant Addiction

	GVG	Gabapentin	Tiagabine	Topiramate	Baclofen
Pharmacological Actions	GABA transaminase inhibitor	GABAmimetic	GABA transporter inhibitor	Positive GABA_A receptor modulator	GABA_B receptor agonist
Self-Administration (SA)	↓ Cocaine SA (FR, PR)	No effect on cocaine SA	↓ SA of low dose cocaine		↓ Cocaine (amphetamine, METH) SA (FR, PR, 2^nd-order)
Reinstatement of Drug-Seeking	↓ Relapse by cocaine	No effect on relapse by cocaine	No effect on relapse by cocaine		↓ Relapse by cocaine, by amphetamine
Conditioned Place Preference (CPP)	↓ CPP by Cocaine or amphetamine				↓ CPP by METH
Enhanced Brain-Stimulation Reward (eBSR)	↓ eBSR by cocaine				↓ eBSR by cocaine
Psychostimulant-like Discriminative Stimulus Effects (DS)	No effect on DS by cocaine	No effect on DS by cocaine	No effect on DS by cocaine	No effect on DS by cocaine	No effect on DS by cocaine
Behavioral Sensitization (BS)	↓ BS by Cocaine	Conflicting	No effect on cocaine BS		↓ BS by cocaine, by amphetamine
Abuse Liability	No SA by itself	Cases reported	No cocain-like DS by itself	No cocain-like DS by itself	No SA by itself
Natural Reward	↓ Food-taking ↓ Sucrose-seeking		↓ Food-taking		↓ Food-taking
Clinical Trials	Phase II	Phase I/II	Phase II	Phase II	Phase II