Table 4.

Pharmacological Actions of CB1 Receptor Antagonists in Animal Models or Paradigms of Psychostimulant Addiction

	SR141716	AM251
Pharmacological Actions	Prototypic CB1 receptor antagonist	Novel CB1 receptor antagonist
Self-Administration (SA)	Conflicting	↓ Cocaine SA (PR, not FR) ↓ METH SA (FR)
Reinstatement of Drug-Seeking (Relapse)	↓ Relapse by cocaine, cues, not stress	↓ Relapse by cocaine
Conditioned Place Preference (CPP)	No effect on cocaine CPP
Enhanced Brain-Stimulation Reward (eBSR)	↓ eBSR by cocaine	↓ eBSR by cocaine
Behavioral Sensitization (BS)	Conflicting	↓ BS by cocaine
Natural Reward	↓ Food-taking	↓ Food-taking
Clinical Trials	Phase III for nicotine and alcohol, but not psychostimulant, dependence	No