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. Author manuscript; available in PMC: 2009 May 7.
Published in final edited form as: Curr Drug Abuse Rev. 2008 Nov;1(3):303–327. doi: 10.2174/1874473710801030303

Table 6.

Pharmacological Actions of Kappa Opioid Receptor Agonists in Animal Models or Paradigms of Psychostimulant Addiction

U50488 U69593 Nalfurafine
Pharmacological Actions Kappa receptor agonist Kappa receptor agonist Kappa receptor agonist
Self-Administration (SA) ↓ Cocaine SA (FR) ↓ Cocaine SA (FR)
Reinstatement of Drug-Seeking (Relapse) ↓ Relapse by cocaine or amphetamine
Conditioned Place Preference (CPP) ↓ CPP by cocaine ↓ CPP by cocaine, amphetamine ↓ CPP by cocaine
Psychostimulant-like Discriminative Stimulus Effects (DS) ↓ DS by cocaine ↓ DS by cocaine, amphetamine ↓ DS by cocaine
Behavioral Sensitization (BS) ↓ BS by cocaine ↓ BS by cocaine, amphetamine
Abuse Liability Cocaine-like DS by itself; Rewarding or aversive by itself; No cocaine-like DS effects; No rewarding effects by itself
Natural Reward Conflicting ↓ Food-taking
Clinical Trials No No No