Table 7.
Pharmacological Actions of Serotonine (5-HT2A, 5-HT2C) Agents in Animal Models or Paradigms of Psychostimulant Addiction
| M100907 | Ro 60-0175 | |
|---|---|---|
| Pharmacological Actions | 5-HT2A antagonist | 5-HT2C agonist |
| Self-Administration (SA) | No effect on cocaine SA | ↓ Cocaine SA (FR, PR) |
| Reinstatement of Drug-Seeking (Relapse) | ↓ Relapse by cocaine or cues | ↓ Relapse by cocaine or cues |
| Conditioned Place Preference (CPP) | ↓ CPP by cocaine | |
| Psychostimulant-like Discriminative Stimulus Effects (DS) | ↓ DS by cocaine | ↑ DS by cocaine |
| Behavioral Sensitization (BS) | ↓ BS by cocaine or amphetamine | ↓ Cocaine-induced hyperactivity |
| Abuse Liability | cocaine-like DS by itself | cocaine-like DS by itself |
| Natural Reward | ↓ food-taking | |
| Clinical Trials | No | No |