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Effects of GnRH analogues and P-X-GnRH-III on colony formation by human tumor cell lines
| Cell line | Surviving colonies, % of control
|
||
|---|---|---|---|
| GnRH-III | Buserelin | P-X-GnRH-III | |
| MCF-7 | 42 ± 8 | 90 ± 2 | 18 ± 10 |
| MDA-MB-231 | 34 ± 7 | 92 ± 2 | 12 ± 7 |
| PC3 | 83 ± 5 | NT | 70 ± 4 |
| Ishikawa | 88 ± 3 | NT | 55 ± 6 |
| LNCaP | 75 ± 5 | NT | 22 ± 10 |
The treatment dose was 50 μM conjugated peptide or free peptide. The number of colonies is expressed as percentage of numbers of control colonies. NT, not tested.
