Figure 3.

PTP inhibition provides lasting functional benefits after spinal cord contusion. A, PBS or PBS with 100 μm bpV(phen) was infused from L5/6 for 28 d, starting 4 h after a contusion at T9. Before the spinal cord contusion, the groups had similar baseline values in the grid-walk test. After the T9 spinal cord contusion, the bpV(phen)-infused group had fewer hindlimb footfalls and reached normal levels. The major effect is during the first week. The columns on the right show that peroxovandadium-treated rats completed the task quicker. p values were less than the numbers over the data points. B, bpV(phen)-treated rats responded to the same Semmes-Weinstein filament sizes applied to the trunk as the PBS rats.