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. Author manuscript; available in PMC: 2009 May 7.
Published in final edited form as: Nat Immunol. 2008 Sep 28;9(11):1225–1235. doi: 10.1038/ni.1655

Figure 6.

Figure 6

C5a upregulates CD11b expression in PMN-MDSCs. (a, b) Induction of CD11b expression on PMN-MDSCs, as determined by flow cytometry analysis, obtained from the spleens (a) or tumors (b) of wild-type (WT) or C5aR-deficient (C5aR-KO) mice, after treatment with PMA or 10 nM C5a. Graphs show fold increase or decrease in the expression of CD11b in stimulated cells vs. baseline (equal to 1) in unstimulated cells from the same mice (WT or C5aR-KO). (c, d) Same analysis as described in (a,b) but for MO-MDSCs. For (a–d), bars represent mean values + SEM (n ≥ 5 mice per cohort). The significance of the induction of CD11b expression was determined using one sample t-test (*, P = 0.0232; **, P = 0.0040; ***, P = 0.0003; ****, P < 0.0001).