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. 2009 Mar 13;18(11):1976–1989. doi: 10.1093/hmg/ddp121

Figure 3.

Figure 3.

Muscle regeneration following notexin injury is impaired in dysferlin-deficient mice. (A) TA muscle from notexin injected mice after 3, 7 or 14 days of recovery and uninjected (control) were stained with haematoxylin and eosin or alizarin Red which detects intracellular calcium. (B) Mean specific force (±SEM) 7 days following notexin injection. Significant deficit in force recovery was found in the dysferlin-deficient strain (P < 0.05; n = 5 C57BL/10, n = 6 C57BL/10.SJL-Dysf). (C) H&E stained sections from C57BL/10 and C57BL/10.SJL-Dysf animals untreated (control), and following a single or three consecutive treatment(s) with notexin to induce muscle regeneration. Three injections of notexin in the C57BL/10.SJL-Dysf strain induce a marked dystrophic phenotype with variation in fibre size, inflammatory infiltration and necrotic fibres, whereas the control (C57BL/10) strain is capable of effective regeneration. Scale bars 100 µm.