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. Author manuscript; available in PMC: 2010 Mar 18.
Published in final edited form as: Int J Pharm. 2008 Nov 5;369(1-2):24–29. doi: 10.1016/j.ijpharm.2008.10.017

Table 1.

Mean pharmacokinetic parameters of ciprofloxacin (unbound) in plasma and dermal ECF (determined by ETS and microdialysis) following administration of 15mg/kg i.v bolus in hairless rats (n=6 ± s.d).

Parameter ETS Microdialysis Plasma
Tmax (min) 30 30 30
Cmax (μg/ml) 0.906 ± 0.046 0.729 ± 0.196 1.695 ± 0.131
AUC0-∞ (min*μg/ml) 88.29 ± 20.41 89.71 ± 25.18 240.33 ± 29.59
t1/2 (min) 55.84 ± 13.44 82.36 ± 22.54 124.12 ±25.99