Figure 4.
Kinetics of virus replication in the upper and lower respiratory tract of BALB/c mice inoculated intranasally with 106 pfu of rRSV/mIFN-γ, rRSV/CAT, or wt RSV. Five mice from each group were sacrificed on the indicated day, the nasal turbinates and lung tissues were removed and homogenized, and the concentration of infectious virus was determined by plaque assay of individual tissue specimens. Mean log10 titer per gram tissue with SD is shown. The limit of virus detection in the upper and lower respiratory tract is indicated.