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Phylogenetic tree of GRX domains from multidomain proteins. CGFS class GRX domains [in green] have less variability in their sequence than CPYC class GRX domains [in mauve]. Note that GRX domains from NrdH-like proteins cluster closer to GRX domains from TRX-GRX fusion proteins, and within the CPYC class. This is consistent with previous results from biochemical assays and sequence analysis that suggest NrdH-like proteins to cluster between TRXs and GRXs [51].
