Table 4.
Top 10 pathway pairs showing significant difference of Z-transformed interaction scores in the DMD data.
| Pathway Pair | # of OGs | IS | dZIS | |
| NM | DMD | |||
| Hs_beta-arrestins in GPCR Desensitization (15) D4-GDI Signaling Pathway (22) |
0 | 0.95 | -0.71 | 14.7 |
| D4-GDI Signaling Pathway (22) Role of arrestins in the activation and targeting of MAP kinases (22) |
0 | 0.94 | -0.65 | 13.2 |
| Eicosanoid Metabolism (25) Lysine_degradation (28) |
0 | 0.94 | -0.66 | 13.2 |
| Regulation of hematopoiesis by cytokines (28) Monoamine_GPCRs (34) |
0 | 0.92 | -0.66 | 12.6 |
| Aspirin Blocks Signaling Pathway Involved in Platelet Activation (35) D4-GDI Signaling Pathway (22) |
0 | 0.90 | -0.68 | 12.3 |
| D4-GDI Signaling Pathway (22) RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage (23) |
0 | 0.79 | -0.80 | 11.5 |
| T Helper Cell Surface Molecules (16) TGF beta signaling pathway (34) |
0 | 0.88 | -0.64 | 11.4 |
| D4-GDI Signaling Pathway (22) Trka Receptor Signaling Pathway (22) |
0 | 0.84 | -0.68 | 11.0 |
| Aspirin Blocks Signaling Pathway Involved in Platelet Activation (35) Msp/Ron Receptor Signaling Pathway (14) |
0 | 0.81 | -0.72 | 10.8 |
| Msp/Ron Receptor Signaling Pathway (14) Roles of arrestin-dependent Recruitment of Src Kinases in GPCR Signaling (28) |
0 | 0.79 | -0.72 | 10.5 |
# of OGs: number of overlapping genes in two gene sets, NM: normal muscle, DMD: Duchenne's muscular dystrophy, dZIS: difference of Z-transformed IS, (): number of genes in a gene set, Nonparametric p value < 8.0E-7.