Table 2.
Genotype frequencies and adjusted odds ratios (and Cornfield 95% confidence intervals) for the CD14-159C/T and TLR9-1237T/C polymorphisms in US patients with different types of upper gastrointestinal cancer and controls
| Esophageal cancer | Gastric cancer | |||||
|---|---|---|---|---|---|---|
| Locus | Genotype | Controls, n |
Squamous, n (%) |
Adeno, n (%) |
Cardia, n (%) |
Noncardia, n (%) |
| CD14-159C/T | C/C | 52 (25) | 14 (27) | 36 (34) | 38 (31) | 53 (29) |
| C/T | 108 (51) | 27 (53) | 47 (44) | 53 (44) | 94 (51) | |
| T/T | 51 (24) | 10 (20) | 24 (22) | 31 (25) | 37 (20) | |
| Adjusted OR (95% CI)a | C/C vs. C/T+T/T | 1.2 (0.6–2.5) | 0.6 (0.4–1.0) | 0.7 (0.4–1.2) | 0.8 (0.5–1.3) | |
| TLR9-1237T/C | T/T | 149 (71) | 40 (77) | 77 (76) | 85 (71) | 139 (78) |
| T/C | 57(27) | 7 (13) | 22 (22) | 31 (26) | 38 (21) | |
| C/C | 4 (2) | 5 (10) | 2 (2) | 4 (3) | 1 (1) | |
| Adjusted OR (95% CI)a | T/T vs. T/C+C/C | 0.7 (0.4–1.5) | 0.8 (0.4–1.31) | 1.1 (0.7–1.8) | 0.6 (0.4–1.0) | |
CI, confidence interval; OR, odds ratio
a
Odds ratios adjusted for age, sex, and race.