Table 1.
EC50, EC99 and cut-off concentrations of pyronaridine, chloroquine, artesunate and quinine in WHO microtest and HRP-2 assay
| WHO Microtest | HRP-2 assay | |||||
| N | EC50 (95%CI) | Cut-off concentration (95%CI) | N | EC50 (95% CI) | EC99 (95%CI) | |
| Pyronaridine | 32 | 1.87 (1.40–2.48) |
9.32 (5.2–13.9) |
15 | 2.03 (1.57–2.63) |
9.03 (6.42–12.69) |
| Chloroquine | 36 | 7.1 (5.2–9.6) |
21.7 (15.4–30.6) |
16 | 5.5 (4.4–6.9) |
19.2 (15.3–24.2) |
| Artesunate | 34 | 2.08 (1.48–2.92) |
9.24 (6.53–13.06) |
12 | 2.25 (1.70–2.99) |
15.24 (10.45–22.24) |
| Quinine | 32 | 272 (210–353) |
873 (723–1053) |
14 | 204 (167–250) |
662 (561–781) |
All values are in nmol/l BMM except for chloroquine (μmol/l blood),
Means and 95% confidence intervals are depicted as antilog of arithmetic mean of log-transformed data