. 2008 Dec 16;276(1659):1137–1146. doi: 10.1098/rspb.2008.1597

Table 2.

GLM results for serotonin (5-HT) activity, measured as 5-HIAA/5-HT, in uninfected and experimentally infected killifish. (Brain region codes defined in §2. Parasite effect indicates the effect of increasing metacercarial density on 5-HT activity. Arrows indicate increased or decreased 5-HT activity, EI, experimentally infected; K, body condition. An asterisk (*) denotes significance after correction for multiple comparisons using FDR. D.f.=1 for all main effects and interactions.)

serotonin activity

	SS	F	p-value	parasite effect	stress effect
hippocampus (Dl) overall model: SS=0.374, F_5,36=6.6, p=0.0003, R²=0.5
metacercarial density	0.150	13.3	0.0010*	note interaction
stress	0.077	6.8	0.0100*
sex	0.021	1.9	0.1820
metacercarial density×stress	0.173	15.4	0.0005*	↓ in non-stressed fish
stress×sex	0.115	10.2	0.0032*		↑ in males
striatum (Vc, Vd) overall model: SS=0.076, F_4,37=4.1, p=0.008, R²=0.3
stress	0.045	9.6	0.004*		note interaction
sex	0.027	5.9	0.020*
K	0.009	1.9	0.180
stress×K	0.036	7.8	0.009*		↑ with ↑ K
hypothalamus (NPO, NPP) overall model: SS=0.040, F_1,35=18.3, p=0.0001, R²=0.4
stress	0.040	18.3	0.0001*		↑ overall
raphe (IR, SR) overall model: SS=0.540, F_4,35=36.2, p=<0.0001, R²=0.8
metacercarial density	0.080	21.6	<0.0001*	↓ overall
stress	0.510	136.6	<0.0001*		note interaction
body mass	0.016	4.4	0.0448*
stress×body mass	0.016	4.4	0.0436*		↑ in large fish