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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Depress Anxiety. 2009;26(5):411–418. doi: 10.1002/da.20543

Table 4.

Prior studies of the association of D2 receptors and dopamine transporters with social anxiety disorder and trait detachment

Author Method Sample Size Regions of Interest Principal Findings
Tiihonen et al., 1997 [123I] ß-CIT SPECT after SSRI 11 GSAD; 11 HC Striatum/White matter Decreased DAT binding in GSAD, t=5.41, p<.001
Schneier et al., 2000 [123I]IBZM SPECT 10 GSAD; 10 HC Striatum/Occipital Cortex Decreased D2 receptor binding in GSAD, t=2.6, p=0.02
van der Wee et al., 2008 [123I] ß-CIT SPECT after SSRI; MRI 12 Medicationnaive GSAD; 12 HC Striatum/Cerebellum Increased DAT binding in GSAD, p=0.011
Schneier et al., 2008 [123I]IBZM SPECT 7 GSAD with OCD; 7 HC Striatum/Occipital Cortex Decreased D2 receptor binding in GSAD with OCD, Z=2.24, p=0.025
Farde et al., 1997 [11C]raclopride PET, Scatchard procedure 24 HC Putamen D2 receptor density correlated with detachment, r=-0.68, P<0.001
Breier et al., 1998 [11C]raclopride PET 18 HC Striatum/Cerebellum D2 receptor binding correlated with detachment, r=-0.49, p=0.04
Laakso et al., 2000 [18F]CFT PET 18 HC Putamen, Caudate/Cerebellum DAT binding in putamen, but not caudate, correlated with detachment, r=-0.45, p<0.04

GSAD=generalized social anxiety disorder subjects; HC=healthy control subjects; OCD = obsessive-compulsive disorder; DAT = dopamine tranporter