Table 1.
Mean (SEM) maximum changes from baseline in sitting blood pressure (BP) and heart rate (HR) with glyceryl trinitrate given after sildenafil and placebo in healthy men
| Hours after sildenafil or placebo | Systolic BP (mmHg) | Diastolic BP (mmHg) | HR (bpm) | |||
|---|---|---|---|---|---|---|
| Placebo | Sildenafil | Placebo | Sildenafil | Placebo | Sildenafil | |
| 1 | −16.6 (2.6) | −28.7 (3.5)** | −11.2 (1.9) | −22.7 (2.7)** | 12.0 (1.2) | 16.8 (1.9)* |
| 4 | −17.5 (2.2) | −20 (2.2) | −17 (1.7) | −18.5 (1.6) | 24.3 (2.7) | 25.5 (2.9) |
| 6 | −17.1 (2.1) | −16.2 (2.4) | −14.4 (0.9) | −17.3 (1.6) | 18.6 (1.7) | 24.7 (2.7)* |
| 8 | −17.0 (3.2) | −18.7 (3.1) | −16.4 (2.1) | −18.5 (1.4) | 23.7 (2.5) | 25.6 (2.9) |
| 12 | −24.3 (2.5) | −23.5 (2.9) | −15.3 (1.4) | −16.2 (2.1) | 15.3 (1.9) | 18 (2.7) |
| 16 | −23.4 (1.8) | −22.6 (2.4) | −16 (1.8) | −19.1 (2.1) | 16.2 (2.7) | 15.5 (3.5) |
| 20 | −18.9 (2.5) | −20.6 (1.9) | −14.3 (1.6) | −15.5 (1.6) | 11.4 (2.0) | 11.8 (2.8) |
| 24 | −21.3 (2.8) | −20.1 (2.3) | −17.4 (1.9) | −18.7 (1.8) | 20.3 (3.1) | 11.8 (2.7)* |
| 48 | −22.2 (2.8) | −16.4 (2.8) | −18 (2.1) | −14.4 (2.1) | 21.1 (2.4) | 14.8 (2.6) |
*
P < 0.05;
**
P < 0.01.