Table 3.

Oral bioavailability of salmon calcitonin (sCT) based on AUC_{0–2 h} of plasma sCT

	IMeal at 18.00 h	IIMeal at 20.00 h	IIIMeal at 21.00 h	IVMeal at 22.10 h	VNo meal
Mean (pg ml−1 min−1)	795	1098	812	1824	3110
[95% CLM]	[454, 1394]	[527, 2291]	[495, 1332]	[1241, 2682]	[1850, 5227]
P-value	0.009	0.06	0.01	0.48	–
Relative oral bioavailability	0.26	0.35	0.26	0.59	= 1.00
[95% CI]	[0.09, 0.73]	[0.12, 1.04]	[0.09, 0.75]	[0.21, 1.68]

Oral bioavailability of sCT based on AUC_{0–2 h} of plasma sCT. The dose was given at 22.00 h. Values of AUC_{0–2 h} of plasma sCT are given as geometric mean and 95% confidence interval of mean (CLM). The P-values represent the Dunnett-adjusted significance of the multiple comparisons of the treatment sequence i, ii, iii and iv against meal treatment sequences v (no meal). The relative oral bioavailability is the bioavailability relative to treatment sequences v (no meal), and the Dunnett-adjusted 95% confidence interval (CI) in the relative bioavailability from treatment sequence v (no meal).