Table 4.
Pharmacodynamic effect on serum CTX-I
| IMeal at 18.00 h | IIMeal at 20.00 h | IIIMeal at 21.00 h | IVMeal at 22.10 h | VNo meal | |
|---|---|---|---|---|---|
| Mean (% h−1) | −91 | −130 | −202 | −235 | −238 |
| [95% CLM] | [−135, −47] | [−177, −84] | [−247, −158] | [−279, −190] | [−282, −193] |
| Difference (% h−1) | 147 | 107 | 35 | 3 | – |
| [95% CI] | [68, 225] | [27, 187] | [−43, 114] | [−77, 83] | |
| P-value | 0.0003 | 0.008 | 0.58 | 1.00 | – |
| Mean (ng ml−1 h−1) | −0.40 | −0.52 | −1.21 | −1.25 | −1.47 |
| [95% CLM] | [−0.74, −0.07] | [−0.87, −0.17] | [−1.55, −0.88] | [−1.57, −0.92] | [−1.79, −1.15] |
| Difference (ng ml−1 h−1) | 1.06 | 0.94 | 0.25 | 0.22 | – |
| [95% CI] | [0.55, 1.58] | [0.42, 1.47] | [−0.26, 0.77] | [−0.32, 0.76] | |
| P-value | <0.0001 | 0.0005 | 0.51 | 0.66 | – |
Pharmacodynamic effect of salmon calcitonin (sCT) based on AUC0–4 h of serum CTX-I. The dose was given at 22.00 h. Values of AUC0–4 h of serum CTX-I are given as mean and 95% confidence interval of mean (CLM). The differences are the differences of AUC0–4 h from treatment sequences v (no meal) and the Dunnett-adjusted 95% confidence interval (CI). The P-values represent the Dunnett-adjusted significance of the multiple comparisons of the treatment sequence i, ii, iii and iv against meal treatment sequences v (no meal).