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Mean plasma concentrations of lapatinib (LAP) from a 100-mg dose given alone (▵) and after treatment with ketoconazole (KTZ) (▴), and from a 250-mg dose given alone (○) and after treatment with carbamazepine (CBZ) (•). LAP (—○—); LAP + CBZ (—•—); LAP (—▵—); LAP + KTZ (—▴—)
