Table 2.

Effect of ketoconazole (KTZ) on lapatinib (LAP) pharmacokinetics

Parameter	LAP alone* (n= 22)	LAP + KTZ* (n= 21)	Comparison† (n= 21)
AUC, h ng−1 ml−1 (range)	1429 (1198, 1704)	5242 (4388, 6263)	3.57 (3.07, 4.15)
Cmax, ng ml−1 (range)	115 (101, 130)	252 (210, 301)	2.14 (1.74, 2.64)
tmax, h	4.0 (2.5, 8.0)	4.0 (2.5, 10.0)	0.75 (0.00, 1.75)
tlag, h	0.25 (0.00, 0.77)	0.25 (0.00, 1.00)	0.12 (0.00, 0.13)
ka, h−1	0.56 (0.44,. 0.72)	0.56 (0.44, 0.73)	1.01 (0.77, 1.32)
t1/2, h	9.6 (8.5, 10.7)	16.0 (14.0, 18.3)	1.66 (1.50, 1.84)

^*Geometric mean (95% CI) for AUC, C_max, k_a, t_1/2; median (range) for t_lag and t_max.

^†Geometric least-squares mean ratio (95% CI) for AUC, C_max, k_a, t_1/2; median difference for t_max and t_lag.