Table 3.

Effect of carbamazepine (CBZ) on lapatinib (LAP) pharmacokinetics

Parameter	LAP alone* (n= 24)	LAP + CBZ* (n= 23)	Comparison† (n= 23)
AUC, h ng−1 ml−1	3526 (2888, 4306)	984 (826, 1171)	0.28 (0.23, 0.32)
Cmax, ng ml−1	261 (209, 327)	110 (90.5, 134)	0.41 (0.34, 0.51)
tmax, h	4.0 (2.5, 6.0)	3.0 (1.0, 8.0)	−0.21 (−0.70, 0.76)
tlag, h	0.12 (0.00, 0.50)	0.25 (0.00, 1.00)	0.00 (0.00, 0.14)
ka, h−1	0.70 (0.59, 0.82)	0.50 (0.39, 0.63)	0.72 (0.54, 0.96)
t1/2, h	10.2 (9.24, 11.3)	9.98 (8.12, 12.3)	0.98 (0.80, 1.19)

^*Geometric mean (95% CI) for AUC, C_max, k_a, t_1/2; median (range) for t_lag and t_max.

^†Geometric least-squares mean ratio (95% CI) for AUC, C_max, k_a, t_1/2; median difference for t_max and t_lag.