Table 2.
The influence of the homozygous UGT1A1*28 genotype on raloxifene species concentrations
| Raloxifene species | Genotype | n | c [nmol l−1] | P | Stat. significance |
|---|---|---|---|---|---|
| M1 | *1/*1, *1/*28 | 37 | 54 ± 8 | 0.025 | S |
| (37, 71) | |||||
| *28/*28 | 10 | 102 ± 24 | |||
| (48, 155) | |||||
| M2 | *1/*1, *1/*28 | 37 | 241 ± 36 | 0.021 | S |
| (167, 314) | |||||
| *28/*28 | 10 | 457 ± 94 | |||
| (243, 670) | |||||
| M1+M2 | *1/*1,*1/*28 | 37 | 295 ± 43 | 0.012 | S |
| (208, 381) | |||||
| *28/*28 | 10 | 558 ± 115 | |||
| (298, 819) | |||||
| RAL | *1/*1,*1/*28 | 37 | 3.3 ± 0.5 | 0.340 | NS |
| (2.4, 4.3) | |||||
| *28/*28 | 10 | 4.3 ± 1.1 | |||
| (1.8, 6.9) |
The values of concentrations are arithmetic means ± standard error, the numbers in parentheses represent 95% confidence intervals.