Table 3.
The changes after 12 months' treatment in measured bone mineral density (BMD) of HIP, FN and L1–L4 in the patient group homozygous for *28 allele compared with the group with at least one copy of the wild-type allele
| Site | Genotype | n | Δ BMD [%] | P | Stat. significance |
|---|---|---|---|---|---|
| HIP | *1/*1, *1/*28, | 45 | 0.3 ± 1.4 | 0.036 | S |
| (−2.4, 3.1) | |||||
| *28/*28 | 11 | 4.4 ± 2.4 | |||
| (−0.9, 9.6) | |||||
| FN | *1/*1, *1/*28, | 45 | 1.6 ± 0.8 | 0.94 | NS |
| (−0.1, 3.2) | |||||
| *28/*28 | 11 | 1.8 ± 1.1 | |||
| (−0.7, 4.2) | |||||
| L1–L4 | *1/*1, *1/*28, | 45 | 2.0 ± 0.7 | 0.59 | NS |
| (0.6, 3.4) | |||||
| *28/*28 | 11 | 2.4 ± 1.3 | |||
| (−0.6, 5.3) |
The differences were tested for significance by the Mann–Whitney test. The values ΔBMD are arithmetic means ± standard error, the numbers in parentheses represent 95% confidence intervals.